This might be caused from the firewall protection. Check the Internet firewall with your system or network administrator.
The firewall may need to have some settings changed in order for the ICA-500 to be accessible outside your LAN.
Make sure that the ICA-500 isn't conflicting with any other web server running on your LAN.
Check the configuration of the router settings allow the ICA-500 to be accessed outside your local LAN.